Handbags and jewellery with an estimated value of over $250,000 have been stolen from a home in the east of Melbourne.

Whitehorse Crime Investigation Unit detectives are appealing for assistance following the burglary in Blackburn on August 3.

The home-owner returned to her Canterbury Road address about 10pm on August 3 to find every room ransacked.

The stolen items include 50 designer handbags worth an estimated $250,000

It’s believed the items were stolen some-time between 12 Noon -10pm on August 3.

Investigators have released footage and images of some of the items taken during the burglary.